Sunday 29 July 2007

What is aging?

Well, many of you will answer: “when time passes you become older”. But this is no scientific answer. You could describe it as getting grey hair, getting wrinkles, getting pigmentation spots,… But again these aren’t scientific answers. Off course these have a biological source but are not the reasons why you get ill or died.
Dr. De Grey defines aging as: "the set of accumulated side effects from metabolism that eventually kills us".
So what happens inside your body when you get older? Dr. De Grey has made a list of 7 causes of aging. This is a part of his SENS (Strategies for Engineered Negligible Senescence) theory.
These are:

1. Cell los or atrophy
2. Nuclear mutations and epimutations
3. Mutations in mitochondrial DNA
4. Cellular senescence
5. Extracellular cross-links
6. Junk outside cells
7. Junk inside cells

We will discuss each of these causes in greater detail in further posts.

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Word list:

Metabolism: the anabolism and the catabolism together.
Anabolism: making bigger molecules from smaller ones inside your body. This process requires energy.
Catabolism: making smaller molecules from bigger ones inside your body. This process relishes energy.
Senescence: the combination of processes of deterioration which follow the period of development of an organism.

Keep healthy

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